Pentoxifylline-tocopherol-clodronate combination: A novel treatment for osteoradionecrosis of the temporal bone.
نویسندگان
چکیده
BACKGROUND Osteoradionecrosis (ORN) of the temporal bone is a complication of radiation therapy that is extremely challenging to manage. METHODS We report the case of a patient treated at our institution and present a review of the literature. RESULTS A 52-year-old woman presented with ORN of the temporal bone 20 years after radiation therapy for an ipsilateral parotid tumor. She failed conservative management, including serial debridements, oral and topical antibiotics/antifungals, and aural lavage. As an alternative to hyperbaric oxygen (HBO) and/or temporal bone resection, treatment with pentoxifylline-tocopherol-clodronate combination (PENTOCLO) was pursued and her condition improved dramatically. CONCLUSION This is the first document use of PENTOCLO to treat ORN of the temporal bone. PENTOCLO may represent an effective nonsurgical management option for ORN of the temporal bone.
منابع مشابه
Pentoxifylline and Tocopherol in the Treatment of Osteoradionecrosis of Jaw – an Update
Osteoradionecrosis of jaw is one of the significant complications of radiotherapy in head and neck cancer patients. This article reviews pathophysiology and newer treatment options for osteoradionecrosis. Newer modalities of treatment include combination therapy of pentoxifylline and tocopherol for osteoradionecrosis. In this article basic information about pentoxifylline and tocopherol and rec...
متن کاملNew approach for the treatment of osteoradionecrosis with pentoxifylline and tocopherol
Osteoradionecrosis (ORN) of the jaw is a significant complication of radiotherapy for oral cavity cancer. In addition to antibiotic medication, treatment options such as hyperbaric oxygen therapy, surgical approaches, and combined therapy with pentoxifylline and tocopherol have been recently introduced. In this review article, we will discuss the definition and classifications of osteoradionecr...
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Over the last decades, several therapeutic options were considered in the treatment of the osteoradionecrosis (ORN) of the mandible, including supportive measures, ultrasound therapy, corticosteroids, hyperbaric oxygen, surgical resection with reconstruction, and, more recently, drugs capable of reversing the fibroatrophic process. Once established, the ORN does not spontaneously disappear and ...
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BACKGROUND Studies of the use of pentoxifylline and α-tocopherol in osteoradionecrosis of the jaw have suggested their efficacy in this condition. We report an initial case series of pentoxifylline and α-tocopherol for patients with bisphosphonate-associated osteonecrosis (BON). METHODS Six cases referred for management of BON were provided pentoxifylline and α-tocopherol in addition to antim...
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BACKGROUND In head and neck cancer patients undergoing radiotherapy, osteoradionecrosis (ORN) of the jaw is one of the major but uncommon complications. Satisfactorily results have been observed while treating ORN patients with upcoming treatment modalities such as combination therapy of pentoxifylline and Vitamin E (PVe). It is believed that in patients undergoing dental extractions, these tre...
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عنوان ژورنال:
- Head & neck
دوره 37 12 شماره
صفحات -
تاریخ انتشار 2015